CPP Bone Infection

Orthopedic surgeons and scientists recognize infection as one of the most serious and distressing complications of orthopedic procedures.  While the incidence of infection is relatively low in elective procedures at 1-2%, the costs and risks of the two-step revision process are high. For traumatic procedures, the risk of infection increases dramatically, with an estimated 27% incidence in civilians and 40% incidence in war injuries. Revision surgeries are associated with a failure rate as high as 50%, leading to loss of function, arthrodesis, amputation, and death.

In the past, this problem has been addressed through improved sterile technique and use of antibiotics. To date we have failed to eliminate costly bone infection, and rising rates of drug-resistant infection signal a new obstacle. As we approach the limit of the effectiveness of current techniques, novel approaches to infection management must be developed.

Bone Infection as an AOTrauma Clinical Priority Program (CPP)

To further the goals of expanding clinical knowledge and improving patient care, AOTrauma has established a new Clinical Priority Program. Under the direction of the AOTrauma Research commission, AOTrauma has acknowledged the challenge posed by bone infection and defined it as the focus of the new CPP. The CPP bone infection will aim to achieve better understanding of bone infection, provide solutions for the most pressing clinical problems and have a positive impact on patient care.

AOTrauma CPP Infection Proposal Project Matrix

Invitro model development
Rat Model

Development of an Infection Registry Ideal Antibiotic segmental spacer development (3D-printed ceramics) Antibody titers for diagnostis and prognosis Educational activities within CPP Bone Infection​
Rabbit Model development Collection, Assessment and Management of Specimens and Data collected from the Antibody Titer study AOCID​ Develop a new blood test for staph infection​
Translation Sciences Large Animal Model
Diabetic obese
murine model for osteomyselitis


Related literature